Objective: Acute and hard-to-heal wounds are a significant burden to both a patient’s quality of life and resources in healthcare systems. Here, we evaluate the outcomes of a non-comparative case series study in which Ringer’s solution-preactivated polyacrylate dressings were used to treat acute and hard-to-heal wounds (the presence of Ringer’s solution provides a wound dressing that allows, upon application, the immediate hydration of the underlying wound tissue). Method: Patients with acute and hard-to-heal wounds were enrolled into an open-labelled, non-comparative observational study. Patients were treated with Ringer’s solution-preactivated polyacrylate dressings to enable wound debridement and wound cleansing for up to 12 weeks. Results: A total of 303 patients were enrolled in the study and 278 were included in the analysis. Wound size decreased, from a median of 3.6cm2 (interquartile range (IQR): 1.2–9.3] at baseline to a median of 2.6cm2 (IQR: 1.1–7.8] at 84 days. Relative wound area reduction (WAR) was 43.1% at 84 days and estimated probability of achievement of a WAR of ≥40% and ≥60% was 68.7% and 53.4%, respectively. Median time to achieve a WAR of ≥40% and ≥60% was 54 days and 75 days, respectively. The median percentage of wound area covered by fibrin had decreased from 50.0% to 10% and granulation tissue had increased from 25% to 50% after 84 days. In addition, periwound skin condition, local signs of infection and pain all showed improvement. The majority of the wounds were assessed as ‘healed’ or ‘better’ at the conclusion of the evaluation period. Conclusion: Based on the findings of this study, the use of Ringer’s solution-preactivated polyacrylate dressings in daily practice has the potential to improve clinical outcomes, including healing, in patients with acute and hard-to-heal wounds.