LINK Scientific Content – Congress Abstract

Keratinocytes under the spotlight: Epithelialization process is essential for wound healing

Scientific Content

Keratinocytes under the spotlight: Epithelialization process is essential for wound healing

Congress Abstract
LINK Congress 2019, Epithelialization
Publication Year
Marjana Tomic-Canic
Approx. reading time
5 min (1 pages)

Key Points

Wound healing, a process that aims at barrier restoration, integrates multiple cell types and cellular processes to achieve closure. Such organized process coordinates multiple cell compartments and processes in spatial and temporal manner by using complex signaling networks and micro-environmental factors.

Keratinocytes, major component of epidermis, play an important role during all phases of wound healing by signaling and crosstalk to other cells, and by migrating and proliferating to close the wound, ultimately achieving barrier restoration and wound closure. Although this ability of skin to maintain barrier and heal wounds is evolutionary conserved and maintained throughout a lifetime of an organism, it fails due to various underlining issues.

Chronic wounds, such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) represent a widespread unmet clinical challenge and major burden on healthcare systems worldwide. Epithelialization is also impaired in these patients. Details of biological functions of keratinocytes during healthy and chronic wound healing will be reviewed. Finally, different approaches to restore keratinocyte biological function and epithelialization capacity in chronic wounds will be discussed.


A comprehensive understanding of the epithelialization process will provide new tools for clinical approaches to facilitate epithelial wound closure.


Marjana Tomic-Canic
University of Miami, Miller School of Medicine, Miami, United States

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