•Chronic wounds place a significant burden for both patients suffering with wounds as well as on the healthcare system.
•Collagen dressings are a category of dressing with the ability to decrease the matrix metalloproteinase (MMP) burden while controlling inflammation and maintaining a moist wound environment.
•MMPs, pro-inflammatory enzymes, have been found to be elevated in non-healing chronic wounds, therefore contributing to a complex wound environment.
•This study tested the use of an advanced wound dressing made from collagen, sodium alginate, carboxymethylcellulose, and ethylenediaminetetraacetic acid (EDTA) with silver* and without silver as a safe and effective treatment to improve healing.
