Wound care quality and speed of burn healing are important factors that affect the treatment, prognosis and complications of burns. Burn care is challenging, and the ideal method is controversial. The aim of this study was to compare the effects of a new dressing (ColActive® Plus Ag) in the treatment of superficial second-degree burns versus traditional dressings including Vaseline and Nitrofurazone. This was a randomized clinical trial study involving 25 cases.