An impaired wound healing, perturbed inflammation is a major clinical challenge.
The initial inflammatory phase becomes chronic and blocking the emergence of a healthy and productive granulation tissue. The microenvironment of the wound changes. Excessive proteases destroy growth factors such as VEGF or HFG involved in tissue angiogenesis and epithelial proliferation and migration. Detailed analysis reveals that the phenotype of macrophages at the early- and late-stages of the inflammatory response are important regulators of granulation tissue formation and interleukin-4 alpha receptor-mediated profibrotic scaring. A clear understanding will help clinicians to effectively treat patients with chronic wounds particularly at the stage of wound bed preparation. Moreover, clinicians will get better insights into fibrotic scaring, a condition causing significant impairment and discomfort for patients.
Authors
Sabine Eming
Professor of Dermatology, Department or Dermatology, University of Cologne, Germany
Read more about these topics
Get access to over 200 scientific abstracts, publications, webinars and E-learning to expand your knowledge of wound management.
I am here to help you to find what you are looking for. (Your virtual assistant)
While I provide information on wound care fundamentals, e-learnings and scientific contents, it's essential to note that my responses are generated based on available data and algorithms. You are encouraged to independently verify the accuracy and suitability of the information provided. Always consult with qualified healthcare professionals for comprehensive guidance on wound care and related matters. I ask you not to enter any personal information. However, if you do, you agree that I process your personal information (including health-related data) that you may provide to me in order to receive an accurate response.
